Concurrently, serum levels of ox-LDL, PAI-1, lipid profile, HOMA-IR, leptin, and high-sensitivity C-reactive protein (hs-CRP) were assessed.<h4>Results</h4>One year after surgery, significant reductions were observed in CIMT, anthropometric parameters, inflammatory biomarkers (leptin, hs-CRP), insulin resistance, ox-LDL, and PAI-1 levels, along with improvement in lipid profile. The gene discussed is LEP; the disease is Insulin resistance.