Collectively, our findings support a CPSF6-APA-iron homeostasis axis as an important co-/post- transcriptional regulatory mechanism in erythropoiesis, and implicate its dysregulation in the pathogenesis of PV, offering novel molecular targets for therapeutic intervention in myeloproliferative neoplasms. The gene discussed is CPSF6; the disease is myeloproliferative neoplasm.