This study aimed to elucidate how IL-17A regulates NETs generation after ischemic stroke.<h4>Methods</h4>Using a mouse middle cerebral artery occlusion (MCAO) model, we administered the Peptidylarginine deiminase 4 (PAD4) inhibitor GSK484 or an IL-17A-neutralizing antibody (IL-17mAb). This evidence concerns the gene PADI4 and ischemic stroke.