Previous studies on WDR34 reported that mutations in WDR34 led to Jeune syndrome or asphyxiating thoracic dystrophy,12 short-rib polydactyly syndrome type III/severe asphyxiating thoracic dysplasia, and can also inhibit the transforming growth factor-β–activated kinase 1 in the NF-κB activation pathway.13 Here, DYNC2I2 is linked to Jeune syndrome.