<h4>Aims</h4>To compare the effects of individual SGLT2 inhibitors on preventing new-onset proteinuria in patients with type 2 diabetes and preserved kidney function.<h4>Materials and methods</h4>A target trial emulation was performed using commercially available databases, including health checkups and claims data, between April 1, 2014 and March 31, 2023. The gene discussed is SLC5A2; the disease is type 2 diabetes mellitus.