Since urinary albumin-to-creatinine ratio (UACR) reflects systemic endothelial dysfunction, we investigated the triple-line pattern (TLP) as a marker of peripheral remodeling and its dose-response relationship with low-grade albuminuria.<h4>Methods</h4>The Subclinical Cardiovascular Disease in Type 1 Diabetes Mellitus (SCVD T1DM) cohort study prospectively recruited 283 adolescents with T1D and 106 age- and sex-matched controls. This evidence concerns the gene ALB and diabetes mellitus.