NFKB1 and Parkinson disease: RESULTS: One thousand one hundred eighty-three DEGs and 518 IRGs were obtained, and 31 genes were in the intersection, among which v-rel reticuloendotheliosis viral oncogene homolog A (RELA, p65), a crucial component in NF-κB signaling, was upregulated in the PD samples and demonstrated good diagnostic efficacy.