Ferrocene (Fc)-modified human serum albumin (HSA) via coupling chemistry was electrostatically complexed with glucose oxidase (GOD) and co-assembled with an azobenzene (AZO)-caged ARV-771 prodrug to yield HSA-Fc-GOD@ARV-771(AZO) nanoparticles that exhibited pH-triggered disassembly in acidic tumor environments. The gene discussed is ALB; the disease is neoplasm.