CXCL8 and neoplasm: Although CXCL8 is elevated in OSCC and linked to tumor progression, its precise pro-metastatic mechanisms and downstream effectors remain unclear.<h4>Methods</h4>To identify key regulators of OSCC metastasis, we integrated bioinformatics analysis of multiple GEO datasets and identified CXCL8 as an upregulated hub gene in OSCC tissues.