<h4>Objective</h4>We are aimed at investigating the association between the size of simple renal cyst (SRC) and the expression of geranylgeranyl pyrophosphate synthase (GGPPS), which can induce renal cyst formation after its deletion.<h4>Methods</h4>Seventy-seven patients who received renal cyst decortication were enrolled. This evidence concerns the gene GGPS1 and cystic kidney disease.