The expression levels of estrogen receptor (ER) (<i>P</i> = 0.009), progesterone receptor (PR) (<i>P</i> < 0.001), and Ki-67 (<i>P</i> < 0.001) show significant differences between the BRCA mutation group and the BRCA non-mutation group.<h4>Conclusions</h4>Compared to BRCA non-mutated patients, BRCA mutated patients in Shenzhen have smaller tumor volumes, with pathological grades mainly at grade 3, and molecular subtypes predominantly being triple-negative breast cancer. This evidence concerns the gene ESR1 and triple-negative breast carcinoma.