LBP was highly expressed in the poor-survival subgroup and functionally validated <i>in vitro</i>: RT-PCR/ELISA/Western blot and cell-based assays showed that LBP promotes tumor-cell migration and macrophage activation, while LBP neutralization reversed these effects, supporting its role as a mediator of tumor-immune crosstalk. The gene discussed is LBP; the disease is neoplasm.