<h4>Background</h4>This study aimed to evaluate the synergistic role of fibroblast growth factor receptor 4 (FGFR4) and inflammatory cytokines (ICs) (interleukin-6 [IL-6], tumor necrosis factor-a [TNF-a], and C-reactive protein [CRP]) in predicting recurrence of differentiated thyroid carcinoma (DTC) after radical surgery, and to develop a combined predictive model for improved postoperative risk stratification.<h4>Methods</h4>We enrolled 102 DTC patients treated between February 2022 and January 2024, along with 98 healthy controls. This evidence concerns the gene TNF and differentiated thyroid carcinoma.