The results of the multivariate Logistic regression analysis showed that age, BMI, SBP TG, TC, BUN, TBIL, and ALT were independent risk factors for the development of diabetes in the pre-diabetic healthcare population within 5 years (P&lt; 0.05).<h4>Conclusions</h4>This study demonstrates that age, BMI, blood pressure, blood lipid levels, liver and kidney function indexes, and gender are significant risk factors for patients with Pre DM to develop into DM. The gene discussed is GPT; the disease is diabetes mellitus.