PPI network analysis identified <i>Acta2, Kdr, and Cxcr4</i> as key target genes mediating tape-stripping-induced food allergy exacerbation.<h4>Conclusion</h4>This study demonstrates that tape-stripping exacerbates food allergy by disrupting epithelial barrier integrity, inducing systemic immune dysregulation, and altering gene expression in intestinal tissues. This evidence concerns the gene KDR and food allergy.