Through a series of experiments, including RNA-seq, Co-IP, Co-IF, WB, and rescue assays, this study demonstrated that INHBA promotes GC progression by targeting ITGA6 to regulate the MAPK signaling pathway.<h4>Conclusions</h4>INHBA/ITGA6/MAPK axis can provide new insights into GC therapy. This evidence concerns the gene ITGA6 and gastric cancer.