Finally, high levels of <i>WRN</i> mRNA expression correlated with significantly longer MFS compared to low mRNA expression levels (<i>p</i> = 0.009, Log Rank).<h4>Conclusions</h4>This study underscores the prognostic significance of moderate penetrance breast cancer risk variant genes, such as <i>ATM</i>, <i>BLM</i>, and <i>WRN</i>, for survival outcomes in eBC. Here, ATM is linked to breast carcinoma.