EZH2 and neoplasm: We subsequently determined the effect of combined eIF4Fi, AKT1 inhibitor, EZH2 inhibitor or VEM on tumor growth <i>in vitro</i> and <i>in vivo</i>.<h4>Results</h4>RocA inhibited proliferation and induced apoptosis in A375 cells, but inhibited proliferation in A375R cells.