This present study aims to elucidate how to overcome the resistance of the eIF4Fi in BRAF<sup>V600E</sup> mutant melanoma cells and explore the underlying mechanisms.<h4>Methods</h4>Melanoma A375 (vemurafenib [VEM]-sensitive) and A375R (VEM-resistant) cells were exposed to eIF4Fi RocA at varying doses and durations <i>in vitro</i>. The gene discussed is BRAF; the disease is melanoma.