OSBPL3 and Patent ductus arteriosus: Single-cell transcriptomic and mass spectrometry data was further integrated with functional validation to explore the regulatory mechanisms through which OSBPL3 modulates PDA malignancy.<h4>Results</h4>OSBPL3 was highly expressed throughout various stages of pancreatic inflammation, precursor lesions, and PDA in both human and mouse pancreatic tissues.