CD8A and neoplasm: RNA-seq and ChIP-seq were further employed to identify downstream targets of CEBPB, and ChIP-qPCR, qPCR, and Western blot were used to further validate these results.<h4>Results</h4>We demonstrated that dormant tumor cells were resistant to ICB and resided within an immunosuppressive niche, characterized by increased M2 macrophages and reduced CD8<sup>+</sup> T cell infiltration.