Specific tumor targeting and imaging contrast were validated <i>in vivo</i> using V2R-expressing tumors.<h4>Results</h4>[<sup>18</sup>F]F-MQ232 is a highly relevant radioligand whose tumor uptake directly correlates with V2R expression levels in tissues, demonstrating its specificity to V2R-expressing tumors. Here, AVPR2 is linked to neoplasm.