Finally, tumor growth and survival were determined upon treatment with [<sup>225</sup>Ac]Ac-DOTA-MSC3 with and without ICI.<h4>Results</h4><sup>111</sup>In- and <sup>225</sup>Ac-labeled DOTA-MSC3 bound specifically to CAIX-expressing hypoxic tumor cells. This evidence concerns the gene CA9 and neoplasm.