The pretreatment of Lenti-C-HOIL-1 to the colon of wild-type mice alleviates DSS-induced intestinal inflammation.<h4>Conclusions</h4>Our results define the pathophysiological role of HOIL-1 cleavage in colitis, and unveil new functions of C-HOIL-1 in regulating myeloid inflammatory responses. This evidence concerns the gene RBCK1 and colitis.