Through multivariate regression analysis, we determined that thrombosis risk was independent of the severity level of depression (O R = 2.10 , p&lt; 0.001), IL-6 levels (O R = 1 .9 2 , p &lt; 0.0 01), and platelet activation (O R = 2.50, p&lt; 0.001).<h4>Conclusions</h4>The results indicate that depression is an independent risk factor for thrombosis, through systemic inflammation and platelet hyperactivity. The gene discussed is IL6; the disease is major depressive disorder.