The combined model (CXCL8 + tumour markers + Adler grade) achieved an AUC of 0.903 (95% CI: 0 .8 5 0 -0 .9 5 7 ), with 86.11% sensitivity and 82.35% specificity (P&lt; 0.001).<h4>Conclusions</h4>High expression of CXCL8 is closely associated with BC ALNM. The gene discussed is CXCL8; the disease is neoplasm.