Therefore, this study aims to analyze the association between the GNB3 c.825C > T polymorphism and obesity in the Taiwanese population using various grouping criteria.<h4>Subjects/methods</h4>The study recruited 372 eligible subjects for GNB3 SNP rs5443 (c.825C > T) testing at China Medical University Hospital in Taichung, Taiwan. The gene discussed is GNB3; the disease is obesity due to melanocortin 4 receptor deficiency.