Furthermore, our results revealed that the C/T and T/T genotypes had higher frequency distributions compared to the C/C genotype in females with body fat percentages below 30 % ( <i>p</i> = 0.022 and <i>p</i> = 0.004, respectively).<h4>Conclusions</h4>Taiwanese individuals carrying the C/C homozygous genotype of the GNB3 gene may have a higher susceptibility to obesity, particularly among females. The gene discussed is GNB3; the disease is obesity due to melanocortin 4 receptor deficiency.