Renal function, oxidative/antioxidant markers, inflammatory cytokines (IL-1β, IL-6, TNF-α, NF-κB), apoptosis, and histopathology were assessed.<h4>Results</h4>CLP-induced sepsis resulted in significant AKI, evidenced by elevated inflammatory and apoptotic markers, oxidative stress, and histopathological damage. Here, TNF is linked to acute kidney injury.