This model identified seven clinically significant genes (<i>EGF</i>, <i>PCOLCE2</i>, <i>CD36</i>, <i>ADAMTS8</i>, <i>CIDEC</i>, <i>KIT</i>, and <i>AKAP12</i>) with notable prognostic value in GC progression. This evidence concerns the gene AKAP12 and gastric cancer.