In atherosclerosis (AS), DAB2IP suppresses the inflammation and apoptosis of endothelial cells (ECs) through the TNF signaling pathways, inhibits phenotypic switching of vascular smooth muscle cells (VSMCs) via the JAK-STAT and PI3K-Akt axes, and attenuates plaque angiogenesis via VEGF-related pathways. The gene discussed is DAB2IP; the disease is atherosclerosis.