These diseases, such as clinically isolated syndrome (CIS), relapsing-remitting multiple sclerosis (RRMS), secondary progressive multiple sclerosis (SPMS), neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), are frequently associated with visual pathway impairment. The gene discussed is MOG; the disease is secondary progressive multiple sclerosis.