Additionally, we discussed adverse events and hypoglycemia.<h4>Methods</h4>We searched PubMed/MEDLINE, Web of Science, and the Cochrane Library from October to November 2025 using the following terms: GLP-1 agonists, semaglutide, tirzepatide, liraglutide, exenatide, children, obesity, adolescents, blood pressure, BMI z, hypoglycemia, body weight, and HbA1c. This evidence concerns the gene GLP1R and Obesity.