HCHR showed moderate discrimination for predicting 28-day mortality (AUC 0.686, 95% CI 0.651-0.722), outperforming hs-CRP and HDL-C alone.<h4>Conclusion</h4>HCHR is independently associated with 28-day all-cause mortality in sepsis and demonstrates moderate discriminative performance. Here, CRP is linked to Sepsis.