<h4>Background</h4>The 2022 European Leukemia Net (ELN) risk stratification categorizes acute myeloid leukemia (AML) with myelodysplasia-related gene (MRG) mutations - including <i>ASXL1</i>, <i>BCOR</i>, <i>EZH2</i>, <i>RUNX1</i>, <i>SF3B1</i>, <i>SRSF2</i>, <i>STAG2</i>, <i>U2AF1</i> and/or <i>ZRSR2</i> - as "adverse-risk". The gene discussed is RUNX1; the disease is acute myeloid leukemia.