Mechanistically, NSUN2 first initiates the m<sup>5</sup>C within YAP mRNA and then ALYREF recognizes m<sup>5</sup>C modification on YAP mRNA, YBX1 was more likely to bind to the transitive m<sup>5</sup>C from ALYREF and then promoted YAP mRNA stability through impeding the combination between AGO2 and YAP mRNA whereby increasing the expression of YAP with interaction with eIF3a and thus excessive cell growth and metastasis via regulation of YAP's target genes of CTGF, Cyr61 MMP2, MMP9 in NSCLC. The gene discussed is CCN1; the disease is non-small cell lung carcinoma.