GLUT1 is highly expressed in the Ph+ ALL and associated with synergy of TKIs with CX-4945; Seahorse assay showed enhanced glycolysis in the patient sample with Ik6<sup>+</sup> Ph+ ALL; GLUT1 knockdown suppresses glycolysis and induces apoptosis in the cells. The gene discussed is SLC2A1; the disease is acute lymphoblastic leukemia.