LGMN and acute lymphoblastic leukemia: In PAR2-knockdown ALL cells, the stimulation of adenylate cyclase (AC) with forskolin or treatment with 8-CPT-cAMP effectively inhibits Lgmn-induced μ-OR1-mediated ER Ca<sup>2+</sup> release, indicating that Lgmn's stimulation of μ-OR1 results in the downregulation of AC and a subsequent decrease in cAMP levels.