<h4>Objective</h4>To evaluate the association between <i>Fusobacterium nucleatum</i> and c-Myc expression in Oral Potentially Malignant Disorders (OPMDs) and Oral Squamous Cell Carcinoma (OSCC) and to explore its potential role in oral carcinogenesis.<h4>Materials and methods</h4>A total of 32 histopathologically confirmed cases (18 OPMDs and 14 OSCC) were analyzed. Here, MYC is linked to oral cavity squamous cell carcinoma.