Finally, we established a THP-1-derived macrophage trained immunity model to validate the paracrine effects of macrophage Maturin (MTURN) and Piezo-type mechanosensitive ion channel component 1 (PIEZO1) in cardiomyocytes.<h4>Results</h4>Seven hub genes were identified from HF-DEGs, the trained immunity transcriptional signature, and WGCNA co-expression modules. Here, PIEZO1 is linked to hydrops fetalis.