FTO and Sepsis: Functional experiments demonstrated that FTO promotes macrophage polarization toward the pro-inflammatory M1 phenotype and enhances neutrophil inflammatory and chemotactic responses, highlighting its critical role in orchestrating inflammatory regulation during sepsis.<h4>Conclusion</h4>FTO, identified through consensus machine learning approaches, could serve as a potential diagnostic biomarker and m<sup>6</sup>A methylation regulator for sepsis.