Subsequently, Western blot technology is used to detect the expression of CCL23 protein in plasma, so as to externally validate the diagnostic value of the aforementioned relevant Hub genes in differentiating Kawasaki disease from other similar diseases.<h4>Results</h4>We identified 11 significant hub genes and found that the concentration of CCL23 in the KD group was significantly higher than that in the febrile control group and the healthy control group. The gene discussed is ELAVL2; the disease is Kawasaki disease.