Behavioral intoxication indices, serum biochemistry, liver oxidative stress markers, inflammatory cytokines, histopathology, lipid accumulation, and the expression of lipid-metabolismrelated genes and proteins (FAS, SCD1, ACC1, CPT1, PGC-1α, PPARα) were assessed.<h4>Results</h4>HQ significantly prolonged alcohol tolerance time (P < 0.01) and shortened sober-up time (P < 0.01). The gene discussed is PPARGC1A; the disease is alcohol dependence.