The effect of HIV infection and clinical presentation on mortality, TPE complications, and renal outcomes were analysed using regression analysis.<h4>Results</h4>TMA is associated with advanced HIV infection (median CD4 count 151 × 106/mm<sup>3</sup> cells and median viral load 117500 copies/mL), usually occurs in the absence of antiretroviral therapy (ART), and shows a predilection for young Black women, reflecting TMA risk factors and local demographics of the HIV pandemic. This evidence concerns the gene CD4 and HIV infectious disease.