This study aimed to establish a zebrafish larval intrahepatic metastasis model and to determine the role of c-Met activation in mediating liver tropism of cancer cells.<h4>Methods</h4>An intravenous injection-based zebrafish model (zLiverMet) was developed using a liver-specific fluorescent reporter line to visualise tumour colonisation in vivo. This evidence concerns the gene MET and neoplasm.