Based on our previous whole genome sequencing (WGS) and whole exome sequencing (WES) data indicating frequent copy number loss of CAPZA1 in ESCC, as well as the presence of a specific single nucleotide polymorphism (SNP, rs373245753 T>G) in its 3'UTR via the dbSNP database (https://www.ncbi.nlm.nih.gov/snp/), we sought to determine the functional and mechanistic impact of CAPZA1 genotypes on ESCC cell behavior.<h4>Materials and methods</h4>We identified the SNP rs373245753 within the 3'UTR of the CAPZA1 gene via the dbSNP database. This evidence concerns the gene CAPZA1 and esophageal squamous cell carcinoma.