Starting from human colon cancer cells showing aberrant WNT/β-catenin/TCF signaling, hyperactivated <i>MYC,</i> and silenced <i>BASP1</i>, we generated stable cell lines overexpressing <i>BASP1</i>, either ectopically, or by reactivating the dormant <i>BASP1</i> promoter using a lentiviral CRISPR-based system. Here, MYC is linked to colonic neoplasm.