The molecular docking results showed that the binding energies of ARG2-SKA-111/cyclophosphamide and ELF3-voruciclib/cyclophosphamide were less than - 5 kcal/mol.<h4>Conclusion</h4>The findings of this study highlight the key roles of ARG2, ELF3, and NKX2-1 in macrophage-related mechanisms of SSc-ILD, providing insights into potential therapeutic targets. Here, NKX2-1 is linked to interstitial lung disease.