Gastrin treatment suppressed these increases (P < 0.05), an effect diminished by CI-988 (P < 0.05).<h4>Conclusions</h4>Gastrin may exert protective effects against ISO-induced HF and myocardial remodeling by inhibiting the JAK2/STAT3 and ERK1/2 pathways via the CCK2 receptor. This evidence concerns the gene GAST and hydrops fetalis.