Additionally, western blotting (WB) analysis of P-JAK2/JAK2, P-STAT3/STAT3, and P-ERK/ERK in cardiac tissues and cells was used to identify pathways through which gastrin modulates HF and myocardial remodeling.<h4>Results</h4>In vivo study, the ISO-treated mice exhibited significantly increased gastrin levels compared to the control group (P < 0.05). This evidence concerns the gene STAT3 and hydrops fetalis.