Therefore, this research explored potential genes with prognostic value related to Tolerogenic dendritic cells in gastric cancer, to identify novel therapeutic targets that could provide valuable insights for the clinical treatment of gastric cancer.<h4>Results</h4>Five prognostic genes (CXCL1, INHBA, ASCL2, RNASE1, and GPX3) were finally obtained to construct the risk model. The gene discussed is ASCL2; the disease is gastric cancer.