Univariate and multivariate logistic regression showed that epileptiform discharge frequency (EDF), background EEG delta wave ratio (BEDWR), stroke lesion volume (SLV), National Institutes of Health Stroke Scale (NIHSS) score, and serum neuron-specific enolase (NSE) levels were independent risk factors for PSE (all <i>P</i> < 0.05). Here, ENO2 is linked to stroke disorder.