Loss of the lncRNA-PRLB/FUS/GPX4 axis sensitized ovarian cancer cells to paclitaxel, suggesting that ferroptosis suppression is a key driver of chemoresistance.<h4>Conclusion</h4>This study identifies lncRNA-PRLB as a critical upstream regulator of ferroptosis resistance and chemoresistance in ovarian cancer. Here, GPX4 is linked to ovarian cancer.